Important in CBD therapeutic applications is the lack of psychotropic effects. Furthermore, this phytocannabinoid is not teratogenic or mutagenic . Until recently, CBD was thought to have only low toxicity to humans and other species , but recent studies indicate an increase in ALT and AST levels after CBD treatment, which disqualifies it as the drug of choice . In addition, it has been found that CBD may interfere with the hepatic metabolism of some drugs by inactivating cytochrome P450 3A and P450 2C . Such interactions should be considered when co-administering CBD with other drugs metabolized by above enzymes. Abnormal CBD (4-[-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol), named O-1602, is a synthetic CBD regioisomer and a selective GPR55 receptor agonist , but not a CB1/CB2 receptor agonist.
Cytokines are small messenger proteins that can stimulate inflammation. Cytokines can be pro-inflammatory and will cause swelling and heat in the tissues as an inflammatory response. The inflammatory process is designed to initially help us with function and repair of injury. However, inflammation that is out of control can lead to diseases such as metabolic syndrome or arthritis. It is no wonder we have developed anti-inflammatory medications to control these effects and have now turned to a more natural relief, cannabidiol .
These compounds are responsible for the positive effects of CBD, so BATCH CBD’s well-rounded products will give you the most bang for your buck. Unlike other CBD companies, BATCH CBD directly manages their products all the way from start to finish. Beginning with seed selection and hemp genetics, BATCH products originate from high-quality, hand-selected hemp plants that are bursting with cannabinoids and terpenes.
Hundreds of studies have demonstrated that CBD can improve many medical conditions. If you are not a regular cannabis user, you will likely experience psychoactive effects. By stimulating the serotonin receptors, CBD is able to prevent the reward-facilitating effects of morphine. CBD induces cancer cell death by stimulating the molecules needed in apoptosis like caspase and ceramide.
In fact, all mammals create their own cannabinoids that work within the system to maintain homeostasis — or balance. If you didn’t learn about the endocannabinoid system in your high school Biology class, that’s because it is a relatively recent discovery. In fact, scientists didn’t know the endocannabinoid system existed until 1992. If company transparency is a top priority for you, the folks at Hemplucid are your people.
Fab CBD uses only the highest quality hemp extract in its products. They use organically grown hemp farmed in Colorado, all pesticide-free. This company has a mission to create the best CBD products on the market and to provide excellent customer service cbd gummies peach to their customers. They cater specifically to the new generation of people who want to live a preventive wellness lifestyle and they also give back to the community. When it comes to their CBD gummies, CBDistillery offers nearly 10 different products.
CBD-rich topicals are often used to treat joint pains, muscle spasms, and other external conditions. They can also be used to deal with acne and other skin problems. While these studies have shown that CBD might be an effective treatment route for diabetes, more research is needed to be carried out in humans. Study published in 2013 in the American Journal of Medicine drew several conclusion about CBD use for diabetes treatment. It concluded that CBD users have high levels of HDL despite eating a regular diet. More importantly, the study confirmed that CBD might help regulate blood sugar, which is crucial to managing type 2 diabetes.
CB2 receptors help regulate the immune system, and in doing so, regulate inflammatory responses. However, in more severe or prolonged cases, this process can cause something known as ‘chronic inflammation’. When inflammation is consistently triggered, it can destructively impact organs and tissues, due to the constant and increased production of these chemicals. This results in oxidative stress – a term coined to explain an imbalance between antioxidants and ‘free radicals’ (free-roaming atoms in the body which cause damage to cells). Naturally, the human body can produce endocannabinoids or neurotransmitters to bind to the nervous system’s cannabinoid receptors. CBD can minimize chronic pain by affecting the activity of the endocannabinoid receptor, thereby interacting with the neurotransmitters and reducing inflammation.
Please consult your healthcare professional about potential interactions or other possible complications before using any product. The statements have not been evaluated by the Food and Drug Administration and the products are not intended to diagnose, treat, cure or prevent any disease or ailment. Acne is a common skin condition that is characterized by excessive production of sebum, causing the pores to become blocked, and then trapped bacteria causes inflammation of the sebaceous glands. Although CBC was discovered over 50 years ago, it’s potential therapeutic benefits are only just starting to come to light with modern scientific research. If you’re intrigued by some of the many possible benefits of CBD use but still on the fence, you might find it helpful to approach the topic from a different angle. Let’s take a look at what CBD is, what it’s not, and how CBD works in the human body.
You should also check with your doctor beforehand that the CBD oil won’t interact negatively with any of your medications. The use of CBD should be avoided during pregnancy and breastfeeding. The consumption of CBD oil can be accompanied by side effects in some cases, although this happens rarely, as the CBD is generally received well and safely. They could include tiredness, a decrease of alertness, nausea, diarrhea, convulsions, or irritability.
Cannabidiol is an extract of the hemp plant, shown to have many health benefits. CBD does not get you high or make people feel stoned; instead, it relieves pain and stimulates relaxation. This occurs without making users dysphoric as traditional opioids do.
Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes. No writing assistance was utilized in the production of this manuscript. And of course you’re invited to contact Mtiva if you have questions about our products. David Perlmutter, MD, FACN is a board-certified neurologist, Fellow of the American College of Nutrition, and five-time New York Times bestselling author. He is recognized internationally as a leader in the field of nutritional influences in neurological disorders.
Top 10 Best Cbd Oil For Inflammation Reviews
Signs of liver injury have additionally been reported in some sufferers, but this is much less common. These merchandise are more effective as a result of all of those compounds come collectively in an entourage effect to work together with one another within the body. CBD helps to halt inflammation by stopping harmful inflammatory brokers from travelling via the physique. As such, many ongoing research are solidifying CBD’s safeness and effectiveness in treating many dangerous inflammatory situations so that folks can perform in higher and more improved methods.
The first thing that you should do is to seek medical attention to find out what the underlying cause of the inflammation is and to obtain any medications that might be necessary to treat the root of the inflammation. But why is the body’s natural response to so many different situations and stimuli to become inflamed? These chemicals are released into your bloodstream and into the surrounding tissues. There have not been many studies into how CBD affects inflammation in humans, but researchers have found evidence to suggest that CBD reduces inflammation and pain in animals.
Stimulates the activity of the endocannabinoid system through several different receptor-independent routes. CBD also strengthens and inhibits the binding action of certain protein-coupled receptors. 2] Delta-9-Tetrahydrocannabinol , on the other hand, binds to CB1 and CB2 receptors, activating them and thus changing a person’s thinking, memory, pleasure, and pain perception, and concentration.
Potential Risks Of Cbd Oil
Because of its anti-inflammatory and antimicrobial properties, CBD is being researched as a complementary therapy. CBD may increase liver enzymes , making it potentially harmful for people with liver disease, or necessitating regular tests for blood liver enzyme levels. CBD is of interest to the research and medical communities because of its potential for health benefits and treatments without the “high” of THC. Based on my experience, CBD can offer relief against pain and inflammation, but that’s only if it’s dosed properly. It may take a few weeks for you to see results, but you definitely will, starting with at least 50 milligrams a day.
2013 study found that CBD treatment can indeed reduce one’s dependence on nicotine or tobacco smoking. In this study, 12 smokers were issued with inhalers infused with CBD oil, while the other 12 participants were given non-CBD inhalers. CBD oil has shown great potential to lessen the level of reward smoker’s brain gets from smoking tobacco, and therefore loosening their dependency on them. It acts like a nicotine patch but without all the side effects and withdrawal symptoms. In this comprehensive study, 24 individuals with social anxiety disorder were given treatment solution containing around 600mg of cannabidiol before going to give a public speech. Extensive review conducted in 2014 concluded that CBD might be a viable treatment option for osteoarthritis pain.
Furthermore, first-timers should always consult their physicians to ensure safety, as some people are hypersensitive to CBD. You can read the ingredients on the product box before buying and choose the one you find the most effective. Non-GMO food is healthy as they are completely natural and full of nutrients.
Because of its antimicrobial properties, CBD is also being studied as a potential new class of antibiotics in response to the current trend in antibiotic resistance. THC cbd cream for herniated disc has a psychoactive effect and is obtained from the marijuana plant. CBD has no psychoactive effects and can be obtained from the marijuana plant or the hemp plant.
Δ9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations. Cannabinoid receptor activation induces apoptosis through tumor necrosis factor α-mediated ceramide de novo synthesis in colon cancer cells. The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis.
Even though some people find that CBD improves symptoms related to depression, human evidence of CBD’s potential antidepressant abilities is currently limited . A study that included survey data from 2,701 people with fibromyalgia found that those who used CBD for pain relief generally reported slight to significant improvement in symptoms . Finally, there is anecdotal wisdom, when experiences by patients and health professionals have positive results. While the experience or medication could be beneficial, that doesn’t mean it is going to work for everyone. That’s because each and every person is unique, and what works perfectly for one patient could have no effect on another patient. This is especially true for pain, where many other factors can affect the perception of pain.
CBD oils have shown to be a good alternative to lab-manufactured drugs. These oils have been tried, tested, and proven to be functional by renowned medical practitioners. CBD oils have since been established to be useful in treating a variety of common ailments such as pain, inflammation, anxiety, epilepsy, arthritis, among others. These ailments are known to cause severe problems where they breed other ailments if they aren’t addressed.
The endocannabinoid signalling system is crucial for inflammatory systems and pain management. CBD oil has excellent potential for reducing inflammation and pain in arthritis patients as, it shows high effectiveness, has a good safety profile and does not seem to produce any side effects. The benefits of topical CBD oil depend on its anti-inflammatory and anti-oxidative effects. THC also stimulates the CB1 receptors in the brain and digestive system to produce antiemetic effects.
Photo credit Matthias ZomerYou probably know someone who suffers from joint pain of some kind — and the older you get, the more likely that is to be true. The Center for Disease Control estimates that almost 23% of Americans suffer from arthritis alone. As an athlete, you can’t avoid inflammation — muscle strains and sprains are an expected part of the job. But for sports like football where head trauma is a job hazard, CBD’s proven neuroprotective properties are just as important. We’ll get into the nitty-gritty of that research later when we talk about Alzheimer’s, but CBD is proving to be a powerful neuroprotectant.
Even if you think you are in the clear, it is always best to ask first. Because Crohn’s can present differently between individuals, treatments are often a matter of trial and error. And traditional medications, while being effective, Helfen CBD Gummibärchen beim Einschlafen? may come with a range of side effects. For example, atJacks Swing Oil, we use a patented technology that ionizes oil-based ingredients like CBD and converts it into SALT to dissolve in water easily (the body is 80% water).
Some evidence suggests full-spectrum products may be more effective, but it really just depends on what you’re comfortable taking. Chronic pain is commonly the result of chronic inflammation, which is caused when the immune system maintains an inflammatory response longer than is necessary or healthy. This type of pain is called inflammatory pain, and nervous system disorders can also cause chronic pain. THC and CBD, the two most studied, provide immune modulation and anti-inflammatory properties. These natural cannabinoids engage with the human endocannabinoid system to change how the body regulates pain by energizing the body’s self-repair system. The product available from CBDmd that we recommend for inflammation relief is their CBD Inflammation Formula.
In this study, we aim to investigate the CBD effect on the aggregation of recombinant human tau protein 1N/4R isoform using biochemical methods in vitro and in silico. Using Thioflavin T assay, circular dichroism , atomic force microscopy , we demonstrated that CBD can suppress tau fibrils formation. Moreover, by quenching assay, docking and job’s plot, we further demonstrate that one molecule of CBD interacts with one molecule of tau protein through a spontaneous binding. Taken together, this study provides new insights about a natural substance, CBD, for tau therapy which may offer new hope for the treatment of AD.
CBD inhibits GPR55 signaling, which is linked to the ability of this cannabinoid to stop the growth of cancer. CBD is known to have a tremendous number of medicinal properties, but because the field of marijuana research is in its infancy, we still need more studies to examine the full potential of the plant’s compounds. There is already a large body of scientific literature and anecdotal evidence that supports CBD’s potential for the treatment of inflammation. Inflammation is a natural response in your body’s immune system. This response is actually extremely important, and it happens all the time both inside and outside of the body, even when we may not notice it. You see, your body is constantly exposed to free radicals, germs, viruses, and other harmful substances that your body doesn’t want.
You can imbibe 20 or even 100 bottles of the concoction and you’ll not suffer from lasting psychological, mental or physical damage. The review confirmed that CBD has a favorable safety profile when compared to existing medication and other treatment options. The second type is Lennox-Gastaut syndrome that develops during early childhood or infancy. Interestingly, Epidiolex is the first FDA-approved drug to be prescribed to patients for the treatment of Lennox-Gastaut syndrome.
On one hand, those treated with CBD did not experience much change in pain when compared with placebo patients. Additionally, men seemed to benefit from CBD more significantly than women in this test. When introduced topically, CBD oil doesn’t affect the systemic issue as it Why are Delta-10 gummies legal? might if it were introduced directly into the bloodstream. Instead, topical CBD is more localized and treats pain in a certain area. Some studies—both preclinical animal and human clinical trials—suggest CBD could be used to help treat people who are dependent on opioids.
Medterra was founded by a group of individuals who were passionate about the power of CBD. This company believes CBD should be available to everyone who wants it and at an affordable price. They use hemp grown and extracted in accordance with strict guidelines set by the Kentucky Department of Agriculture. Every product is thoroughly tested by independent labs to ensure quality, potency, and safety.
If you have cancer and are interested in using CBD or other cannabis-derived products, it’s important to consult your healthcare team. These products may not be safe, appropriate, or effective for all people with cancer. CBD oil has shown promise as a treatment for some mental health disorders, such as anxiety disorders, leading many people who live with these conditions to become interested in this natural approach. And according to preclinical evidence from rodent studies, CBD may have beneficial effects on pain and inflammation related to arthritis, but human studies are lacking . The human body contains a specialized system called the endocannabinoid system, which is involved in regulating a variety of functions, including sleep, appetite, pain sensation, and immune system response . I’m bedbound 20 to 23 hours a day with spine problems and in pain everyday and on morphine and other pain meds.
Research shows that people who take CBD oil have an increased sleep time in lower instances of insomnia, especially for those who have chronic pain and have a hard time falling asleep or staying asleep due to their pain. Cbd is very safe in comparison to the medical treatment for many of the conditions We discussed. It works in harmony with the body to heal, rather than just masking the symptoms. Cannabidiol or CBD has become incredibly popular as a natural remedy for everything from relieving anxiety to reducing seizures. It is a plant-based chemical compound that can be extracted from the cannabis plant and infused into various products like CBD oils, CBD gummies, and even topical CBD products.
Broad-Spectrum CBD – This CBD contains all of the beneficial compounds found in hemp except for the THC. Penguin CBD gummies are made with pure CBD isolate, so they don’t contain any THC. They are flavored with a mix of natural and artificial flavors and, unfortunately, do contain some corn syrup as well as artificial colors. If you’re looking for a bright, fun gummy that looks like your favorite candy, however, this is it. What makes Penguin CBD unique from other CBD gummy brands is that they offer gummy worms.
While his condition remained mostly in remission, he would occasionally experience inflammatory pain episodes. Although these episodes were tolerable, if they struck at night, they would keep him up. Inflammation is a body-wide phenomenon and manifests differently from person to person.
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So, technically, CBD is federally legal if it was derived from industrial hemp. That means the plant should contain no more than 0.3 percent of THC. A 2016 study, researchers found that bipolar people experienced fewer mental impairments and had a better mood when they used CBD oil. Although most naysayers say cannabinoids can affect memory and thinking, this study seems to show otherwise. By acting on or influencing CB2 receptors and inducing production of serotonin, CBD plays a key role in helping people suffering from PTSD by preventing them from retrieving their nightmares and traumatic memories. The good news is that myriads of research and groundbreaking studies have linked CBD oil with numerous health benefits for your ticker, blood flow and circulation system.
What Does Cannabis Do For Inflammation?
In one such study, researchers administered CBD to people with heroin use disorder. Over the course of a week, CBD significantly reduced heroin users’ cue-induced cravings, withdrawal anxiety, resting heart rate and salivary cortisol levels. 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When CBD is accompanied by an entourage of other cannabinoids and terpenes, the CBD is more effective, and so are the other cannabinoids and terpenes. CBG is often called the “mother cannabinoid” since all other cannabinoids start as CBG. Some CBG remains in the plant, but much of it breaks down into the other 100+ cannabinoids that exist. Selective cultivation has resulted in hemp plants that retain high percentages of CBG. A custom blend of Full Spectrum CBD boosted with CBG, CBC and organic essential oils for powerful relief from discomfort and inflammation. Figure 4 Chemical structures of the most common phytocannabinoids found in the hemp plant.
IL17 and IFNγ production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis. 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. Cannabinoids, the active components of Cannabis sativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 . One study may find that the cannabinoid receptors mediate the function of the molecule and they prove it using clever systems like genetic knockout mice or antagonists of the receptor. With many causes of autoimmunity, there are often distinct locations where the damage occurs.
It was shown that CBD, acting similarly to the classic antioxidant butylated hydroxytoluene , prevents dihydrorodamine oxidation in the Fenton reaction . In addition, CBD has been found to decrease β-amyloid formation in neurons by reducing the concentration of transition metal ions . There have been studies that have found CBD as an inhibitor for breast cancer cells as well. This means that the tinctures can be used as a preventative measure against cancer.
One of the two farms that provide Spruce with organic industrial hemp is located in Kentucky, and the other is in Colorado. Many of these research findings have been published, such as this one which was published in 2009 by the National Center for Biotechnology Information . So, now that you know why inflammation can potentially occur and how exactly it can impact your overall physical, mental and emotional wellbeing, what exactly can you do to prevent or treat the symptoms of inflammation?
Endocannabinoids are part of a neurotransmitter system that promotes relaxation and regulates other body functions like sleep, hunger, memory, and even aspects of the immune system. They have been touted as big players in the maintenance of homeostasis in the body. These products are not intended to diagnose, treat, cure, or prevent any disease. The claims are based on the personal experiences of our customers.
However, it acts by influencing cannabinoid receptors called CB2, which trigger an increase of happy-making hormone, serotonin. It also led to great improvement in sleep quality and less pain during movement. One study published in 2010 investigated the effects of CBD-rich cannabis on 177 cancer patients. The vast majority of these people couldn’t get pain relief from conventional medication. Several preclinical studies and trials to help understand the role of CBD-rich cannabis in managing or relieving pain and other symptoms related to back pain, chronic pain, arthritis, etc.
It can nourish hair from the roots and eliminate inflammation-causing microbes. The oil showcases anti-oxidant effects which, can help prolong wrinkling and sagging of the skin. In addition, they found that many skincare companies were adding it to their products as, they claimed it had skin moisturizing and brightening effects. Word of mouth and the internet is promoting more people to try topical CBD oil for this condition.
CBD oil has been used to safely treat insomnia and anxiety in children with post-traumatic stress disorder , a type of anxiety disorder . In a Brazilian study, 57 men received either oral CBD or a placebo 90 minutes before they underwent a simulated public speaking test. The researchers found that a 300-mg dose of CBD was the most effective at significantly reducing anxiety during the test . More recently, scientists have discovered that certain components of cannabis, including CBD, are responsible for its pain-relieving effects. Clinical trials are fervently underway to try to answer the myriad of questions the new legal status of CBD has ushered in. With CBD status now mostly legal in the US and Europe and the rest of the world taking a renewed interest in it pharmacologically, studies that can accurately answer CBD dosage questions are underway.
The most common symptoms of inflammation include pain, heat, redness, and swelling. Typically, inflammation is treated with anti-inflammatory medications, including both non-steroidal anti-inflammatory drugs and steroid medications. Herodotus wrote about early ceremonial practices by the Scythians, thought to have occurred from the 5th to 2nd century BCE. In modern culture, the spiritual use of cannabis has been spread by the disciples of the Rastafari movement who use cannabis as a sacrament and as an aid to meditation.
And then there’s this 2015 review I found that was published in the Bioorganic and Medicinal Chemistry journal, which talked about CBD’s anti-inflammatory properties. According to the review, CBD can reduce inflammation via a number of pathways in the body, and can be an effective treatment for several health conditions characterized by inflammation. Inflammation and oxidative stress are involved in many diseases.
The FDA seems to be ramping up enforcement to tackle this problem. We tested dozens of products amongst our staff, and through our network of RA readers and found Spruce CBD to be the most effective. The one you choose will depend largely on the location and severity of your pain.
Below we’ll take a closer look at the use of CBD for pain and explore some of the best CBD gummies in depth. Studies show positive results for CBD’s ability to help with addiction to other substances. It’s possible to become psychologically dependent on any substance , but CBD does not have any chemically addicting properties. It is also best to apply CBD 1-2 times per day every 6-8 hours as the CBD bioavailability for topical applications lasts 6-8 hours.
In addition, there are other symptoms that are just as troublesome, such as anxiety and depression. Not only that, but it can become especially trying when you have to contend with other medical problems that tend to coexist with arthritis, like heart disease, diabetes, and obesity. This was the most shocking benefit that I found with CBD and that’s its anti-cancer properties. When I say something like cell death, it might sound like a bad thing, but when it comes to cancer, It’s a wonderful, positive effect of CBD. In the case of CBD, studies have shown that it can stimulate cell death in certain types of cancers, shrinking tumors and inhibiting the growth and spread of Cancerous cells amongst your body. Cbd has gained its popularity and has been most famously known for showing promise for children who suffer from Epilepsy.
Interestingly, there is also a gradual increase in the occurrence of terms related to diseases or to natural compounds, the most prominent being sulforaphane, curcumin, and resveratrol that modulate the Nrf2 pathway. China has become the most prolific producer of Nrf2 papers the last five years followed by the USA and Japan, a reverse pattern compared to the past. In conclusion, Nrf2 is the subject of a globally active research field that keeps growing and extends from bench to bedside. The therapeutic active ingredient present in marijuana and hemp plant is noted for its strong anti-inflammatory properties. For those suffering from autoimmune diseases, the inflammation is seen as a dangerous proposition; continuous swelling can lead to damage of nerve and muscle tissue. While full-spectrum CBD contains the full array of cannabinoids and other beneficial compounds extracted from the cannabis plant, broad-spectrum CBD has been isolated for the cannabidiol.
Cannabinoids As Novel Anti
For example, CBD oils are often sold in 30ml (~1 ounce) bottles with concentrations ranging from 25mg to 2,500mg, sometimes higher. The higher the total concentration of the product, the higher the mg of CBD per serving. Some CBD products like gummies and other edibles tend to be lower in concentration, so be sure to check the label. Full-Spectrum CBD – This extract contains the full array of cannabinoids, terpenes, and other compounds found naturally in hemp. It is an all-American company that uses organic ingredients, plus everything is lab tested for quality and safety.
With 1500 mg of CBD per bottle, this tincture offers impressive potency for a reasonable price. Featuring organic MCT coconut oil as a carrier, this lab-tested broad-spectrum CBD tincture includes high CBD concentrations without packing any artificial ingredients that you don’t want in your body. Study from 2016 suggests that this Bonbons au CBD terpene might offer anti-parasitic benefits. On brand websites, social media profiles, Facebook groups, reviews on blogs, and open forums like Reddit. This told us a lot about the value companies and individual products have to offer. Sol CBD offers a wide range of highly bioavailable CBD products all lab tested for quality.
Are self-prescribed by many respondents who suffer from excruciating pain for emergency pain relief. The analgesic property of CBD eradicates the option of using standard medicines and compels a patient to embrace a natural method. Healthworx CBD offers isolates, broad-spectrum, and full-spectrum CBD products that use non-GMO, pesticide-free hemp, according to the lab reports on most of the products.
We saw they have over star Google reviews, and the stories are pretty amazing. While they don’t make any health claims , their products clearly work for a variety of people with a variety of needs. This is a San Diego based company that specializes in analytical services, including cannabinoid potency testing, terpene profiling, and pesticide screening. Not only do they create well-rounded products, they only use the highest quality ingredients. This includes pesticide free, unadulterated American-grown hemp along with natural flavors.